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    * Hematology101 SEARCH *

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    Prof. Dr. med. Thomas Reinbold - Witten/Herdecke University
    Resident at St.-Marien-Hospital Lünen, Medical Clinic II, Gastroenterology, Oncology, Metabolic and Infectious Diseases, Clinic Director Dr B. med. Lenfers 06/2009 - 09/2010

    apl.-Prof. Dr. med. Carsten Krüger - Witten/Herdecke University
    Clinical competencies Paediatrics and adolescent medicine Neonatology Paediatric gastroenterology Paediatric cardiology Infectiology Endocrinology

    Dr. med. Priv.-Doz. Leonard Fehring - Witten/Herdecke University
    Press expert for Artificial intelligence in medicine Automated doctor's letter writing Big data in gastroenterology and registry studies The human factor in digitalisation in healthcare Digital health applications Cost-benefit assessments of digital innovations

    Prof. Dr. Michael Paulussen - Witten/Herdecke University
    Medical Director, Chief Physician for General Paediatrics, Paediatric Haematology and Oncology, Gastroenterology and Rheumatology, Cardiology and Pulmonology, Vestische Kinder- und Jugendklinik Datteln, Chair of Paediatrics, Faculty of Health, Witten/Herdecke University

    Univ.-Prof. Dr. med. Ekkehart Jenetzky - Witten/Herdecke University
    Univ.-Prof. Dr. med. Ekkehart Jenetzky Professor Faculty of Health (School of Medicine) | Chair of Medical Theory, Integrative and Anthroposophic Medicine

    Prof. Dr. med. Kai Hensel - Witten/Herdecke University
    Clinical competencies Paediatric gastroenterology, hepatology and nutrition (incl. upper and lower endoscopy of the digestive tract)

    Univ.-Prof. Dr. Anja Ehrhardt - Witten/Herdecke University
    Univ.-Prof. Dr. Anja Ehrhardt Chair Holder Faculty of Health (School of Medicine) | Chair of Virology and Microbiology Department Management Faculty of Health (School of Medicine)

    Prof. Dr. Markus Heiss - Witten/Herdecke University
    Research specialisations Clinical development of a trifunctional bispecific antibody in gastrointestinal tumours, which led to the approval of the antibody Catumaxomab for direct cytotoxic therapy as well as dendrite-mediated tumour vaccination in peritoneal carcinomatosis and malignant ascites in 2009 Hernias: DFG-funded Biolap study, Lapsis study Endoscopic treatment of anastomotic ...

    Magdalena Wendt - Witten/Herdecke University
    Magdalena Wendt, M. Sc.; M. A. Researcher Faculty of Health (School of Psychology and Psychotherapy) | Chair of Clinical Psychology and Psychotherapy III Researcher Faculty of Management, Economics and Society (Department of Management and Entrepreneurship) | WIFU Endowed Chair for Organisation and Development of Business Families Researcher Faculty of Management, Economics and Society ...

    Univ.-Prof. Dr. med. David Martin - Witten/Herdecke University
    O0066 BONE DENSITY AND STRUCTURE IN CYSTIC FIBROSIS PATIENTS. Journal of Pediatric Gastroenterology and Nutrition, 39 (Supplement 1), S32–S33. https://doi.org/10.1097/00005176-200406001-00068 (Publiziert) Wehner, F., Martin, D. D., & Wehner, H.-D. (2004). Asphyxia due to pacifiers—case report and review of the literature.

     

     

     

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    Hematology Symptoms
    • Fatigue and Weakness: Persistent lack of energy caused by anemia, where reduced red blood cell levels limit oxygen delivery to body tissues.
    • Unexplained Bruising and Petechiae: Easy bruising or pinpoint red spots on the skin resulting from low platelet counts or impaired blood clotting mechanisms.
    • Frequent or Recurrent Infections: Increased susceptibility to illness due to leukopenia or dysfunctional white blood cells failing to protect against pathogens.
    • Swollen Lymph Nodes: Painless enlargement of lymph glands in the neck, armpits, or groin often associated with hematologic malignancies like lymphoma or leukemia.
    • Unexplained Fever and Night Sweats: Systemic symptoms frequently tied to active hematologic disorders or hypermetabolic states driven by bone marrow dysfunction.
    • Shortness of Breath and Palpitations: Respiratory distress or rapid heart rate during light activity as the cardiovascular system attempts to compensate for severe anemia.
    • Bone or Joint Pain: Deep, aching discomfort caused by the expansion of abnormal blood cells within the bone marrow space.

      

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    Hematology History
    • 1658: Discovery of Red Blood Cells Jan Swammerdam becomes the first person to observe red blood cells under a microscope in frog blood, followed closely by Antonie van Leeuwenhoek in human blood.
    • 1901: Discovery of ABO Blood Groups Karl Landsteiner identifies the A, B, and O blood groups, laying the scientific foundation for safe blood transfusions and earning the Nobel Prize.
    • 1910: First Description of Sickle Cell Anemia James B. Herrick publishes the first detailed medical account of elongated, sickle-shaped red blood cells in a dental student from Grenada.
    • 1940: Identification of the Rh Factor Karl Landsteiner and Alexander Wiener discover the Rh factor, drastically reducing fatal transfusion reactions and resolving hemolytic disease of the newborn.
    • 1948: First Remission of Childhood Leukemia Sidney Farber demonstrates that aminopterin (a folic acid antagonist) can achieve temporary remissions in acute lymphoblastic leukemia, marking the birth of modern cancer chemotherapy.
    • 1957: First Successful Human Bone Marrow Transplant E. Donnall Thomas performs the first successful intravenous infusion of bone marrow stem cells into leukemia patients treated with radiation therapy.
    • 1960: Discovery of the Philadelphia Chromosome Peter Nowell and David Hungerford identify a specific chromosomal abnormality in chronic myeloid leukemia, establishing the genetic basis of cancer.
    Current Hematology Research
    • Gene Therapy for Sickle Cell Disease: Advances in CRISPR-based gene editing are enabling targeted modifications in patient hematopoietic stem cells to restore healthy hemoglobin production.
    • CAR-T Cell Innovations in Hematologic Malignancies: Next-generation chimeric antigen receptor T-cell therapies are expanding target antigens to overcome resistance mechanisms in relapsed leukemia and lymphoma.
    • Minimal Residual Disease (MRD) Tracking: High-throughput sequencing and digital PCR techniques are improving early detection of residual cancer cells to guide personalized treatment timelines.
    • Bispecific Antibodies in Multiple Myeloma: Dual-targeting immunotherapies are showing high response rates by simultaneously binding to tumor antigens and cytotoxic T cells to induce targeted lysis.
    • Novel Factor VIII Mimetic Agents for Hemophilia: Long-acting subcutaneous non-factor replacement therapies continue to lower bleeding rates and reduce the burden of frequent intravenous infusions.
    • JAK Inhibitors in Myelofibrosis: Targeted kinase inhibition therapies are demonstrating significant efficacy in reducing splenomegaly and improving constitutional symptoms in chronic myeloproliferative neoplasms.
    • Complement System Targeted Therapies in PNH: Next-generation C3 and C5 complement inhibitors offer improved control over extravascular hemolysis in paroxysmal nocturnal hemoglobinuria.

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